爱游戏app赞助的罗马

冯赛祥

冯赛祥

 学科:预防兽医学
电子邮件:fengsx@scau.edu.cn
通讯地址:广东省广州市天河区五山路483号爱游戏app赞助的罗马办公楼401


简介


冯赛祥,男,微生物学博士,讲师,硕士生导师。任职于爱游戏app赞助的罗马传染病教研室,人兽共患病防控制剂国家地方联合工程实验室。研究兴趣:微生物基因工程,合成生物学。主要从事动物病原细菌基因功能研究及基因工程疫苗的开发;细菌素生物合成机制及抗菌活性研究;生物合成佐剂的研发等。先后主持国家自然科学基金,国家重点研发计划项,参与其他国家及省部级课题多项。以第一作者或通讯作者在Journal of Agricultural and Food Chemistry,Applied and Environmental Microbiology,Veterinary Research及Veterinary Microbiology等杂志发表SCI论文14篇,获授权发明专利13项,曾以访问学者身份在美国Virginia Tech及香港科技大学进行访问研究。


教育经历


2010-09 至 2014-06,华南农业大学,微生物学,博士

2007-09 至 2010-07,华南农业大学,生物化学与分子生物学,硕士

2003-09 至 2007-06,华南农业大学,生物科学,学士


工作经历


2017-10至今,华南农业大学,兽医爱游戏app赞助的罗马,讲师

2019-12至2020-04,香港科技大学,Department of Chemistry,访问学者

2014-11至2017-07,华南农业大学,兽医爱游戏app赞助的罗马,博士后

2013-09至2014-05,Virginia Tech,Virginia-Maryland College of Veterinary Medicine,访问学者


研究领域


动物病原菌遗传及基因功能研究。

动物病原菌基因工程疫苗的开发。

细菌素的生物合成机制与应用。

纳米抗体及亚单位疫苗的研发。


承担科研项目情况


(1)国家重点研发计划(2022YFD1801003),禽重要病毒病新型基因工程亚单位疫苗创制,2022-11-30至2025-12-31,子课题主持。

(2)国家重点研发计划(2022YFD1800904),新型载体疫苗研发,2022-11-30至2025-12-31,子课题主持。

(3)国家自然科学基金(31802203),副猪嗜血杆菌磷酸葡萄糖变位酶功能及其与脂寡糖合成关系的研究,2018-08-16至2021-12-31,项目主持。

(4)广东省企业科技特派员(GDKTP2021017300),副鸡嗜血杆菌A、B和C型遗传改造及生产工艺优化,2021-11-05至爱游戏app赞助的罗马-10-31,项目主持。

(5)横向课题,家禽新型专用佐剂的研究,2020-07-13至2021-12-31,项目主持。


代表论著(*通讯作者)


1.Jiang, J.; Zhao, Y.; Chen, A.; Sun, J.; Zhou, M.; Hu, J.; Cao, X.; Dai, N.; Liang, Z.; Feng, S. *, Efficient markerless genetic manipulation of Pasteurella multocida using lacZ and pheSm as selection markers. Appl Environ Microbiol 爱游戏app赞助的罗马, e0204323.

2.Zhang, G.; Lin, M.; Qin, M.; Xie, Q.; Liang, M.; Jiang, J.; Dai, H.; Xu, S.; Feng, S. *; Liao, M. *, Establishing Heterologous Production of Microcins J25 and Y in Bacillus subtilis. J Agric Food Chem 爱游戏app赞助的罗马, 71 (14), 5600-5613.

3.Liu, P.; Dong, X.; Cao, X.; Xie, Q.; Huang, X.; Jiang, J.; Dai, H.; Tang, Z.; Lin, Y.; Feng, S. *; Luo, K. *, Identification of Three Campylobacter Lysins and Enhancement of Their Anti-Escherichia coli Efficacy Using Colicin-Based Translocation and Receptor-Binding Domain Fusion. Microbiol Spectr 爱游戏app赞助的罗马, 11 (2), e0451522.

4.Han, Y.; Li, Y.; Zeng, Z.; Li, W.; Feng, S. *; Cao, W. *, Resistance Mechanism and Physiological Effects of Microcin Y in Salmonella enterica subsp. enterica Serovar Typhimurium. Microbiol Spectr 2022, e0185922.

5.Li, Y. #; Han, Y. #; Zeng, Z.; Li, W.; Feng, S. *; Cao, W. *, Discovery and Bioactivity of the Novel Lasso Peptide Microcin Y. J Agric Food Chem 2021, 69 (31), 8758-8767.

6.Feng, S. *; Chen, A.; Wang, X.; Pan, Z.; Xu, S.; Yu, H.; Zhang, B.; Liao, M. *, The Glaesserella parasuis phosphoglucomutase is partially required for lipooligosaccharide synthesis. Vet Res 2020, 51 (1), 97.

7.Zhou, Y. #; Feng, S. #; He, X.; Zhou, Q.; Wang, Y.; Yue, H.; Tang, C.; Zhang, B., Surface-exposed loops L7 and L8 of Haemophilus (Glaesserella) parasuis OmpP2 contribute to the expression of proinflammatory cytokines in porcine alveolar macrophages. Vet Res 2019, 50 (1), 105.

8.Feng, S.; Xu, C.; Yang, K.; Wang, H.; Fan, H.; Liao, M., Either fadD1 or fadD2, Which Encode acyl-CoA Synthetase, Is Essential for the Survival of Haemophilus parasuis SC096. Front Cell Infect Microbiol 2017, 7, 72.

9.Zhou, Q. #; Feng, S. #; Zhang, J.; Jia, A.; Yang, K.; Xing, K.; Liao, M.; Fan, H., Two Glycosyltransferase Genes of Haemophilus parasuis SC096 Implicated in Lipooligosaccharide Biosynthesis, Serum Resistance, Adherence, and Invasion. Front Cell Infect Microbiol 2016, 6, 100.

10.Feng, S. X.; Ma, J. C.; Yang, J.; Hu, Z.; Zhu, L.; Bi, H. K.; Sun, Y. R.; Wang, H. H., Ralstonia solanacearum fatty acid composition is determined by interaction of two 3-ketoacyl-acyl carrier protein reductases encoded on separate replicons. BMC microbiology 2015, 15, 223.

11.Feng, S.; Xu, L.; Xu, C.; Fan, H.; Liao, M.; Ren, T., Role of acrAB in antibiotic resistance of Haemophilus parasuis serovar 4. Vet J 2014, 202 (1), 191-4.

12.Zou, Y. #; Feng, S. #; Xu, C.; Zhang, B.; Zhou, S.; Zhang, L.; He, X.; Li, J.; Yang, Z.; Liao, M., The role of galU and galE of Haemophilus parasuis SC096 in serum resistance and biofilm formation. Vet Microbiol 2013, 162 (1), 278-84.

13.Zhou, S. M.; Xu, C. G.; Zhang, B.; Feng, S. X.; Zhang, L. Y.; Zou, Y.; Liao, M., Natural IgG antibodies in normal rabbit serum are involved in killing of the ompP2 mutant of Haemophilus parasuis SC096 strain via the classical complement pathway. Vet J 2013, 196 (1), 111-3.

14.Zhang, B.; Xu, C.; Zhang, L.; Zhou, S.; Feng, S.; He, Y.; Liao, M., Enhanced adherence to and invasion of PUVEC and PK-15 cells due to the overexpression of RfaD, ThyA and Mip in the Delta ompP2 mutant of Haemophilus parasuis SC096 strain. Vet Microbiol 2013, 162 (2-4), 713-23.

15.Xu, C.; Zhang, L.; Zhang, B.; Feng, S.; Zhou, S.; Li, J.; Zou, Y.; Liao, M., Involvement of lipooligosaccharide heptose residues of Haemophilus parasuis SC096 strain in serum resistance, adhesion and invasion. Vet J 2013, 195 (2), 200-4.

16.Zhang, B.; Xu, C.; Zhou, S.; Feng, S.; Zhang, L.; He, Y.; Liao, M., Comparative proteomic analysis of a Haemophilus parasuis SC096 mutant deficient in the outer membrane protein P5. Microb Pathog 2012, 52 (2), 117-24.

17.Zhang, B.; He, Y.; Xu, C.; Xu, L.; Feng, S.; Liao, M.; Ren, T., Cytolethal distending toxin (CDT) of the Haemophilus parasuis SC096 strain contributes to serum resistance and adherence to and invasion of PK-15 and PUVEC cells. Vet Microbiol 2012, 157 (1-2), 237-42.

18.Zhang, B. #; Feng, S. #; Xu, C.; Zhou, S.; He, Y.; Zhang, L.; Zhang, J.; Guo, L.; Liao, M., Serum resistance in Haemophilus parasuis SC096 strain requires outer membrane protein P2 expression. FEMS Microbiol Lett 2012, 326 (2), 109-15.


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